LCE1B (late cornified envelope 1B) encodes a precursor protein of the cornified envelope in the stratum corneum, the outermost layer of the epidermis 1. The protein functions through protein binding interactions to contribute to keratinocyte terminal differentiation and keratinization 1. LCE1B is part of a functionally related gene cluster on chromosome 1 that plays critical roles in epidermal barrier formation 2. In disease contexts, LCE1B expression is dysregulated in inflammatory skin conditions: IL-17A suppresses LCE1B expression in psoriatic epidermis, indicating its importance in psoriasis pathogenesis 1. LCE gene polymorphisms, including those affecting LCE1B, are significantly associated with psoriasis vulgaris susceptibility in multiple populations 2. Additionally, LCE1B was identified as a top candidate gene in transcriptomic cross-talk between periodontitis and hypothyroidism, suggesting broader immunological relevance 3. LCE1B expression is also elevated in HPV-positive head and neck squamous cell carcinomas 4. Clinically, LCE genotypes influence therapeutic response to anti-TNF treatments in psoriasis patients, with deletion polymorphisms predicting poorer treatment outcomes 5.