LGALS3BP (galectin 3 binding protein) is a secreted extracellular matrix protein that plays critical roles in cell adhesion, neural development, and disease pathogenesis. In neural development, LGALS3BP regulates neural progenitor cell positioning and delamination, with genetic variants associated with altered cortical gyrification and sulcal depth in humans 1. The protein mediates extracellular matrix interactions involved in neural progenitor anchoring and migration during corticogenesis 1. LGALS3BP functions through direct binding to integrin αV, facilitating release of active TGF-β1 from latent complexes, which activates downstream fibrotic signaling pathways 2. In pathological contexts, elevated LGALS3BP levels correlate with hepatic fibrosis severity and hepatocellular carcinoma progression 2, non-alcoholic fatty liver disease 3, and tamoxifen-resistant breast cancer metastasis 4. The protein promotes cancer cell adhesion to extracellular matrix and angiogenesis 4, while hepatocyte-derived LGALS3BP in extracellular vesicles induces vascular smooth muscle cell calcification 5. Additionally, LGALS3BP serves as a target for antibody-drug conjugate therapy, inducing immunogenic cell death and enhancing tumor-infiltrating lymphocytes in neuroblastoma models 6. These findings establish LGALS3BP as a multifunctional secreted protein central to development, tissue homeostasis, and disease progression.