LIPK (lipase family member K) is an epidermal acid lipase belonging to the AB hydrolase superfamily 1. It plays a highly specific role in the final stages of keratinocyte differentiation and lipid metabolism within the most differentiated epidermal layers, contributing to the cornification process. LIPK exhibits lipase activity and participates in lipid metabolic processes, showing lipoprotein lipase activity 1. At the molecular level, LIPK is part of a conserved gene cluster of acid lipases found across mammalian genomes, containing 9 coding exons 1. It displays restricted tissue expression primarily in epidermal tissues, distinguishing it from other acid lipases with broader or different tissue distribution patterns 1. Clinically, LIPK has emerged as a disease-relevant biomarker in multiple contexts. It was identified as one of five proteins in a prognostic signature for COVID-19 disease severity, along with Afamin, I-309, NKG2A, and PRS57, achieving 98.04% diagnostic accuracy 2. Additionally, LIPK was identified as a susceptibility gene for psoriasis through rare loss-of-function variant analysis in Han Chinese populations 3. Genetic studies also implicate LIPK in gestational diabetes mellitus pathogenesis through its role in lipolysis and lipid metabolism 4. These findings suggest LIPK has broader systemic significance beyond epidermal function.