Lactoperoxidase (LPO) is a heme-containing oxidoreductase that catalyzes the conversion of thiocyanate (SCN⁻) into the antimicrobial agent hypothiocyanous acid (OSCN⁻) and iodide (I⁻) into hypoiodite (IO⁻) in the presence of hydrogen peroxide, serving as a crucial component of innate immune defense 1. The lactoperoxidase system demonstrates antibacterial properties against diverse pathogens including Pseudomonas aeruginosa, Burkholderia cepacia, and Haemophilus influenzae 1. LPO is present in mammary, salivary gland secretions, tears, and airways, contributing to host defense against infection and airway protection 1. Beyond antimicrobial functions, LPO may protect cells from hydrogen peroxide-induced oxidative damage and inflammation. In pathological contexts, peroxidase-mediated processes including LPO contribute to mucin cross-linking in IL-13-activated airway epithelial cells, potentially promoting pathologic mucus gel formation in asthma 2. Lipid peroxidation (LPO), distinct from the enzyme, is associated with multiple diseases including atherosclerosis, inflammatory bowel disease, keloid formation, and neurodegeneration 3456. Elevated lipid peroxidation levels correlate with increased disease severity in amyotrophic lateral sclerosis, particularly in smoking patients 7. The lactoperoxidase enzyme has potential therapeutic applications in food preservation, oral care, and immunomodulation 1.