LRRC49 is a leucine-rich repeat protein that functions as a subunit of the tubulin polyglutamylase complex (TPGC), which mediates polyglutamylation of cilia and flagella—a process essential for their biogenesis and motility. The protein localizes to centriolar satellites and associates with microtubules. In kidney tissue, LRRC49 is highly enriched in podocyte foot processes, suggesting specialized roles in epithelial cell organization 1. Disease relevance includes pancreatic cancer, where LRRC49 was identified as part of a seven-gene prognostic signature that stratifies patients into distinct risk groups with differential survival outcomes and immune infiltration patterns 2. In breast cancer, LRRC49 expression is frequently reduced through bidirectional promoter hypermethylation (57.5% of tumors), with reduced expression correlating with hypermethylation status; the gene is co-regulated with THAP10 and responds to estrogen stimulation 3. LRRC49 variants also show association with coronary artery disease susceptibility in East Asian populations 4. These findings suggest LRRC49 functions beyond cilia/flagella biology, with potential roles in cell differentiation and cancer-related processes, though mechanistic details remain to be elucidated.