LSM14B — LSM family member 14B

5 sources retrieved · Most recent: April 2026 · Index updated 5 months ago

72PubMed Papers

#6,596 · top 34% of 19K genes

20Diseases

top 45%

0Drugs

0Pathogenic Variants

Experimental GO EvidenceSwiss-Prot Reviewed

RNA bindingprotein bindingovarian follicle developmentoogenesisresponse to antihypertensive drugFemale infertility due to fertilization defectfemale infertility due to oocyte meiotic arrestoocyte/zygote/embryo maturation arrest 22

AI Summary

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LSM family member 14B

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations20

response to antihypertensive drugOpen Targets

0.23Weak

Female infertility due to fertilization defectOpen Targets

0.07Suggestive

female infertility due to oocyte meiotic arrestOpen Targets

0.06Suggestive

oocyte/zygote/embryo maturation arrest 22Open Targets

0.06Suggestive

food allergyOpen Targets

0.06Suggestive

oocyte maturation defect 14Open Targets

0.06Suggestive

oocyte maturation defect 5Open Targets

0.06Suggestive

oocyte maturation defect 9Open Targets

0.06Suggestive

mixed connective tissue diseaseOpen Targets

0.04Suggestive

malignant renal pelvis neoplasmOpen Targets

0.04Suggestive

hepatocellular carcinomaOpen Targets

0.04Suggestive

heart conduction diseaseOpen Targets

0.04Suggestive

dermatophytosisOpen Targets

0.03Suggestive

metabolic diseaseOpen Targets

0.03Suggestive

multinodular goiterOpen Targets

0.03Suggestive

neoplasmOpen Targets

0.03Suggestive

Abnormality of the gastrointestinal tractOpen Targets

0.03Suggestive

liver disorderOpen Targets

0.03Suggestive

exostosisOpen Targets

0.03Suggestive

malunion fractureOpen Targets

0.03Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Brain

100%

Heart

55%

Ovary

52%

Bone Marrow

37%

Liver

33%

Lung

33%

Gene Interaction Network6 neighbors

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StructureAlphaFold

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AlphaFoldAI-predicted · UniProt Q9BX40

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ConstraintgnomAD v4.1

LOEUFⓘ

0.38Moderately Constrained

pLIⓘ

1.00Intolerant

Observed/Expected LoF0.21 [0.12–0.38]

Rankings2 dim

Where LSM14B stands among ~20K protein-coding genes

#6,558of 20,598
Most Researched72
#1,787of 17,882
Most Constrained (LOEUF)0.38 · top 10%