LSM14B — LSM family member 14B

5 sources retrieved · Most recent: April 2026 · Index updated 21 days ago

72PubMed Papers

#6,596 · top 34% of 19K genes

20Diseases

top 45%

0Drugs

0Pathogenic Variants

Experimental GO EvidenceSwiss-Prot Reviewed

RNA bindingprotein bindingovarian follicle developmentoogenesisresponse to antihypertensive drugFemale infertility due to fertilization defectfemale infertility due to oocyte meiotic arrestoocyte maturation defect 14

AI Summary

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LSM family member 14B

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations20

response to antihypertensive drugOpen Targets

0.25Weak

Female infertility due to fertilization defectOpen Targets

0.07Suggestive

female infertility due to oocyte meiotic arrestOpen Targets

0.07Suggestive

oocyte maturation defect 14Open Targets

0.06Suggestive

oocyte maturation defect 5Open Targets

0.06Suggestive

oocyte maturation defect 9Open Targets

0.06Suggestive

food allergyOpen Targets

0.06Suggestive

Hydatidiform MoleOpen Targets

0.05Suggestive

hereditary persistence of fetal hemoglobin-sickle cell disease syndromeOpen Targets

0.05Suggestive

hemoglobin D diseaseOpen Targets

0.05Suggestive

oocyte maturation defect 13Open Targets

0.05Suggestive

oocyte/zygote/embryo maturation arrest 21Open Targets

0.05Suggestive

premature ovarian failure 19Open Targets

0.05Suggestive

oocyte maturation defect 12Open Targets

0.05Suggestive

female infertility due to zona pellucida defectOpen Targets

0.05Suggestive

oocyte maturation defect 11Open Targets

0.05Suggestive

oocyte maturation defect 3Open Targets

0.05Suggestive

oocyte maturation defect 6Open Targets

0.05Suggestive

oocyte maturation defect 7Open Targets

0.05Suggestive

Rare genetic female infertilityOpen Targets

0.05Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Brain

100%

Heart

55%

Ovary

52%

Bone Marrow

37%

Liver

33%

Lung

33%

Gene Interaction Network6 neighbors

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StructureAlphaFold

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AlphaFoldAI-predicted · UniProt Q9BX40

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ConstraintgnomAD v4.1

LOEUFⓘ

0.38Moderately Constrained

pLIⓘ

1.00Intolerant

Observed/Expected LoF0.21 [0.12–0.38]

Rankings2 dim

Where LSM14B stands among ~20K protein-coding genes

#6,558of 20,598
Most Researched72
#1,787of 17,882
Most Constrained (LOEUF)0.38 · top 10%