LSM6 (LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated) encodes a component of Like-Sm (LSm) protein complexes that play essential roles in RNA processing. LSM6 functions as part of the nuclear LSm2-8 complex, which binds specifically to the 3'-terminal U-tract of U6 snRNA and participates in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP complex involved in spliceosome assembly 1. The protein also contributes to the cytoplasmic LSm1-7 complex, which is involved in mRNA degradation by facilitating the decapping step in the 5'-to-3' mRNA decay pathway 2. Structurally, LSM6 displays the canonical Sm fold and participates in the assembly of hexameric LSm657 rings as an intermediate in the formation of functional heptameric LSm complexes 3. Recent proteome-wide association studies have identified LSM6 as significantly associated with attention-deficit/hyperactivity disorder (ADHD), suggesting its potential involvement in neurodevelopmental processes 45. Additionally, LSM6 has been implicated in neurogenesis regulation in the developing Xenopus visual system, where its depletion affects neural progenitor cell proliferation and neuronal differentiation 6. The nuclear localization of LSM6 is controlled by LSM8, which regulates the cellular distribution of LSm proteins and affects processing body formation 7.