LTB4R (leukotriene B4 receptor) is a G protein-coupled receptor that serves as the high-affinity receptor for leukotriene B4 (LTB4), a potent chemoattractant mediating inflammation and immune responses 1. The receptor activates phosphatidylinositol-calcium second messenger systems to modulate immune cell recruitment and inflammatory processes 2. LTB4R functions as a co-regulator of pain sensitization pathways in concert with TRPV1, contributing to nociception and hyperalgesia 2. Beyond inflammation, LTB4R has emerged as an oncogenic factor in multiple malignancies. In clear cell renal cell carcinoma, LTB4R promotes proliferation, migration, and invasion while inhibiting apoptosis through AKT/mTOR signaling pathway phosphorylation 3. In acute myeloid leukemia, elevated LTB4R expression correlates with poor overall survival and serves as an independent prognostic indicator, with expression linked to immune checkpoint genes and leukemogenesis pathways 4. Pan-cancer analyses reveal LTB4R generally associates with negative prognosis, except in hepatocellular carcinoma where high expression is protective 5. LTB4R is also upregulated in chr14 inflammatory conditions including atopic dermatitis and asthma 67. These findings position LTB4R as a potential therapeutic target across inflammatory, immune, and malignant disease states.