MZF1 (myeloid zinc finger 1) is a transcription factor that binds DNA and regulates gene expression through RNA polymerase II-mediated mechanisms 1. As a primary function, MZF1 acts as a transcriptional regulator controlling promoters of genes including PADI1 and CDH2 12. During keratinocyte differentiation, MZF1 binding to the PADI1 promoter drives expression of peptidylarginine deiminase 1, with increased activity correlating with cellular differentiation 1. In osteoblasts, MZF1 cooperates with Sp1/Sp3 transcription factors to regulate N-cadherin promoter activity, influencing cell adhesion 2. Clinically, MZF1 dysregulation is associated with cancer progression. MZF1 functions as an oncogenic transcription factor promoting cancer invasion and metastasis across solid tumors 3. In neuroblastoma, MZF1 independently predicts poor prognosis (hazard ratio=2.330) and facilitates aerobic glycolysis by increasing hexokinase 2 and phosphoglycerate kinase 1 expression 4. MZF1 also drives proline synthesis gene expression to promote neuroblastoma aggressiveness 5. Additionally, MZF1 participates in hepatitis B virus replication through core promoter regulation 6. The MZF1-AS1 long non-coding RNA enhances gastric cancer peritoneal metastasis by stabilizing RAB13 mRNA through NSUN2-mediated m5C methylation 7. These findings identify MZF1 as a therapeutic target for cancer and viral infections.