NMUR2 (neuromedin U receptor 2) is a Gq/11-coupled G protein-coupled receptor that serves as the primary central nervous system receptor for the neuropeptides neuromedin U (NMU) and neuromedin S (NMS) 1. NMUR2 activation triggers phospholipase C and adenylate cyclase signaling pathways, modulating diverse physiological processes including energy homeostasis, feeding behavior, stress responses, circadian rhythms, and inflammatory signaling 23. The receptor's CNS-predominant distribution distinguishes it functionally from the peripherally-expressed NMUR1 4. Clinically, NMUR2 exhibits pleiotropic disease associations. A genome-wide association study identified rs2961757 near NMUR2 as significantly associated with shared genetic risk between asthma and COPD, with NMUR2 variants increasing asthma risk while suppressing COPD development 5. NMUR2 activation also promotes cancer progression; NMU-NMUR2 signaling induces invasive phenotypes in colorectal cancer cells through ERK1/2 activation and increased integrin expression 6. Additionally, NMUR2 was identified as upregulated in gastric intestinal metaplasia, a precancerous lesion 7. Therapeutically, selective NMUR2 agonists show promise for treating obesity, eating disorders, Alzheimer's disease-related memory impairment, and sleep disturbances 3. However, recent pharmacological studies reveal that selective compounds may have unexpected off-target effects on other GPCRs, requiring careful characterization for clinical development 8.