2 sources retrieved · Most recent: April 2026 · Index updated 16 days ago
ⓘGeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
5PubMed Papers
4Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
plasma membraneolfactory receptor activitynervous system processdetection of chemical stimulus involved in sensory perception of smellfamilial hemolytic anemiagoutovarian cancersystemic lupus erythematosus
OR52M1 is an olfactory receptor, a G protein-coupled receptor (GPCR) localized to the plasma membrane with odorant receptor activity. Based on limited published evidence, OR52M1 has been genetically associated with autism spectrum disorder (ASD) 1. Recent research indicates altered expression of OR52M1 in ASD and suggests its involvement in ASD development, though its specific ligand and physiological role in the central nervous system remain largely uncharacterized 2. OR52M1 represents an orphan GPCR with emerging therapeutic potential for autism and related psychiatric conditions.
1
OR52M1 is genetically associated with autism spectrum disorder and included among olfactory receptors with therapeutic potential for ASD
PMID: 375744912
OR52M1 shows altered expression in autism spectrum disorder; identified as an orphan olfactory GPCR with potential roles in ASD development and therapeutic target potential
PMID: 40538218⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
familial hemolytic anemiaOpen Targets
ovarian cancerOpen Targets
systemic lupus erythematosusOpen Targets
No pathogenic variants reported on ClinVar for this gene.
No tissue expression data available for this gene.