OR52M1 is an olfactory receptor, a G protein-coupled receptor (GPCR) localized to the plasma membrane with odorant receptor activity. Based on limited published evidence, OR52M1 has been genetically associated with autism spectrum disorder (ASD) 1. Recent research indicates altered expression of OR52M1 in ASD and suggests its involvement in ASD development, though its specific ligand and physiological role in the central nervous system remain largely uncharacterized 2. OR52M1 represents an orphan GPCR with emerging therapeutic potential for autism and related psychiatric conditions.