PRR5 (proline rich 5) is an associated subunit of mTORC2 that regulates cell growth and survival in response to hormonal signals 1. As a core mTORC2 component, PRR5 participates in growth factor-activated signaling that is nutrient-insensitive, contrasting with mTORC1 1. PRR5 functions upstream of Rho GTPases to regulate actin cytoskeleton organization, likely through activation of Rho-type guanine nucleotide exchange factors 1. Beyond its canonical mTORC2 role, PRR5 plays important regulatory functions in PDGFRB expression and platelet-derived growth factor signaling 2. Notably, PRR5 may act as a tumor suppressor in breast cancer, with substantial downregulation observed in a subset of breast tumors and cancer cell lines, potentially mediated by epigenetic mechanisms 3. In triple-negative breast cancer, PRR5 has been implicated in a lncRNA-driven signaling pathway that activates AKT independently of PI3K, linking it to poor patient survival 2. Additionally, PRR5 genetic variants associate with binge eating behavior in bipolar disorder patients, suggesting roles in food intake regulation 4. Dysregulation of PRR5 expression has been identified in tuberculosis progression and may affect ferroptosis pathways in monocytes 5. PRR5 DNA methylation patterns show promise as biomarkers for antipsychotic response prediction in first-episode psychosis 6.