RAB43 is a small GTPase belonging to the RAS oncogene family that serves as a key regulator of intracellular membrane trafficking and vesicle transport. The protein controls retrograde transport from the endocytic pathway to the Golgi apparatus and is required for maintaining structural integrity of the Golgi complex 1. RAB43 also regulates anterograde ER-to-Golgi transport of G-protein-coupled receptors (GPCRs), including adrenergic and muscarinic receptors, through direct interaction mechanisms that are neuron-specific 2. Additionally, RAB43 mediates the cell surface transport of CD91, a phagocyte recognition receptor critical for macrophage-mediated clearance of apoptotic cells (efferocytosis) 3. In disease contexts, RAB43 demonstrates significant clinical relevance as a cancer-associated gene. Elevated RAB43 expression correlates with poor prognosis in multiple cancer types, including hepatocellular carcinoma, gastric cancer, and gliomas, where it promotes cell proliferation, migration, and epithelial-mesenchymal transition through PI3K/AKT signaling pathways 456. A germline mutation (A158T) in RAB43 has been identified in a hereditary liver-colon cancer syndrome, suggesting its role as a tumor predisposition gene 7. These findings establish RAB43 as both a fundamental regulator of cellular trafficking and a potential therapeutic target in cancer.