RBM14 is a multifunctional RNA-binding protein with diverse cellular roles spanning transcriptional regulation, DNA damage response, and cellular homeostasis. RBM14 functions as both a transcriptional coactivator (isoform 1) and repressor (isoform 2), modulating activities of other coactivators including NCOA6 and CITED1 1. The protein plays a critical role in DNA damage response by participating in the canonical non-homologous end joining (cNHEJ) pathway, where it interacts with KU80 and is recruited to DNA damage sites in a PARP- and RNA polymerase II-dependent manner 23. RBM14 facilitates generation of RNA:DNA hybrids at double-strand break sites, contributing to efficient DNA repair 3. Additionally, RBM14 assembles into the HDP-RNP complex with HEXIM1 and NEAT1, serving as a platform for IRF3 phosphorylation and innate immune response activation through the cGAS-STING pathway 4. The protein regulates cellular O-GlcNAcylation by promoting ubiquitin-dependent degradation of OGA, with its own O-GlcNAcylation at serine 521 affecting oncogenic properties 5. RBM14 is frequently overexpressed in cancers including lung adenocarcinoma and gallbladder cancer, where it promotes tumor progression through metabolic reprogramming and alternative splicing regulation 67.