HNRNPA2B1 is a multifunctional RNA-binding protein that serves as a key reader of N6-methyladenosine (m6A) RNA modifications and regulates diverse aspects of RNA metabolism 1. The protein recognizes m6A-bearing RNAs through direct binding and mediates nuclear RNA processing events, including alternative splicing and primary microRNA processing by interacting with the Microprocessor complex protein DGCR8 1. HNRNPA2B1 plays critical roles in innate immunity by sensing nuclear viral DNA during infection, subsequently undergoing demethylation and cytoplasmic translocation to activate the TBK1-IRF3 pathway for interferon production 2. In neurodegeneration, HNRNPA2B1 associates with oligomeric tau and m6A-modified RNA transcripts, forming complexes that contribute to translational stress responses and are elevated in Alzheimer's disease brains 3. The protein also promotes cancer progression through m6A-dependent stabilization of oncogenic RNAs, including NEAT1 in gastric cancer chemoresistance 4 and ILF3 in multiple myeloma 5. Additionally, HNRNPA2B1 is implicated in stress granule formation and pathological protein accumulation in ALS/FTD 6. These diverse functions establish HNRNPA2B1 as a central regulator linking m6A modification to RNA fate determination in both physiological and pathological contexts.