THOC7 (THO complex subunit 7) is a conserved component of the THO/TREX mRNA export complex with multifaceted cellular roles. Primary function: THOC7 participates in mRNA export from the nucleus and maintenance of genome stability 1. Mechanism: THOC7 localizes to the nucleus through direct interaction with FMIP, a nucleocytoplasmic shuttling protein 2. Genome-wide analysis reveals THOC7 occupancy at repetitive sequences including microsatellite and telomeric repeats in transcriptionally active regions 1. Additionally, THOC7 negatively regulates antiviral innate immunity by promoting proteasomal degradation of TBK1, thereby suppressing type I interferon production in response to RNA virus infection 3. Disease relevance: THOC7 expression dysregulation associates with schizophrenia risk, with reduced expression detected in dorsolateral prefrontal cortex of affected individuals; polygenic risk based on THOC7 and related genes correlates with white matter integrity deficits 4. Clinical significance: THOC7 dysregulation has been identified in cutaneous squamous cell carcinoma, where the THOC7-AS1/OCT1/FSTL1 regulatory axis promotes epithelial-to-mesenchymal transition and tumor progression; THOC7-AS1 antisense oligonucleotides show therapeutic potential 5. THOC7 also exhibits altered DNA methylation in COPD and cervical cancer tissues 67.