RPL11 (ribosomal protein L11) is an essential component of the large ribosomal subunit (LSU) that plays critical roles in protein synthesis and cellular stress responses 12. As part of the 5S ribonucleoprotein particle, RPL11 is required for LSU formation and rRNA maturation 345. Beyond its structural role in ribosomes, RPL11 serves as a key mediator of nucleolar stress responses by inhibiting MDM2-mediated p53 degradation, thereby coupling ribosome biogenesis to p53 activation when ribosomal function is disrupted 567. RPL11 haploinsufficiency causes Diamond-Blackfan anemia 7, a hereditary anemia characterized by impaired erythropoiesis 89. In cancer contexts, RPL11's interaction with c-Myc and its role in nucleolar stress pathways make it relevant for tumor suppression mechanisms 1011. The protein's dysfunction affects mitochondrial metabolism and eIF5A hypusination in erythroid progenitors, linking ribosomal protein function to cellular energy metabolism 8. RPL11 expression is also altered in neurodegenerative diseases, with upregulation observed in brain capillaries of Alzheimer's disease patients 12.