1 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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18PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
UFM1-modified protein reader activityprotein quality control for misfolded or incompletely synthesized proteinsrescue of stalled cytosolic ribosomeendoplasmic reticulumneurodegenerative diseasemigraine disorderpreeclampsiaaneurysm
Based on limited published evidence, SAYSD1 functions as a ufmylation 'reader' component in translocation-associated quality control 1. It recognizes and binds ufmylated ribosomes when translation stalls, promoting transport of stalled nascent chains via the TRAPP complex to lysosomes for degradation 1. This mechanism is essential for removing clogged substrates and maintaining protein quality control at the endoplasmic reticulum during ribosomal rescue.
1
SAYSD1 is a ufmylation reader that binds ufmylated stalled ribosomes and promotes transport via TRAPP complex to lysosomes for degradation
PMID: 36848233⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
neurodegenerative diseaseOpen Targets
migraine disorderOpen Targets
medical procedureOpen Targets
myocardial infarctionOpen Targets
coronary artery diseaseOpen Targets
bladder calculusOpen Targets
Increased blood pressureOpen Targets
nephrolithiasisOpen Targets
essential hypertensionOpen Targets
Moderate albuminuriaOpen Targets
spermatogenic failure 8Open Targets
diabetes mellitusOpen Targets
partial chromosome Y deletionOpen Targets
spermatogenic failure 1Open Targets
type 2 diabetes mellitusOpen Targets
No pathogenic variants reported on ClinVar for this gene.