Based on limited published evidence, SAYSD1 functions as a ufmylation 'reader' component in translocation-associated quality control 1. It recognizes and binds ufmylated ribosomes when translation stalls, promoting transport of stalled nascent chains via the TRAPP complex to lysosomes for degradation 1. This mechanism is essential for removing clogged substrates and maintaining protein quality control at the endoplasmic reticulum during ribosomal rescue.