SCAMP1 (secretory carrier membrane protein 1) is a highly conserved integral membrane protein functioning in post-Golgi recycling and endocytic pathways 1. The protein localizes to insulin secretory granules, trans-Golgi network, recycling endosomes, and clathrin-coated vesicles, where it undergoes palmitoylation to regulate exocytosis and membrane trafficking 2. SCAMP1 mediates protein trafficking and cell surface recycling, with particularly important roles in maintaining cell-cell adhesions through cooperation with metastasis suppressor MTSS1 in breast cancer 3. Dysregulation of SCAMP1 is implicated in multiple cancers. In pancreatic and gallbladder cancers, SCAMP1 overexpression correlates with lymph node metastasis and promotes cell migration and invasion through VEGF signaling 4. In osteosarcoma and renal cell carcinoma, lncRNA SCAMP1 promotes tumorigenesis via miR-26a-5p/ZEB2 and miR-429 axes, respectively 56. Conversely, in acute myeloid leukemia treated with chemotherapy, higher SCAMP1 expression associates with favorable prognosis and longer overall survival 7. SCAMP1 also functions as a host restriction factor against hepatitis B virus replication by suppressing viral promoters 8. In type 2 diabetes, palmitoylated SCAMP1 on insulin granules regulates glucose-stimulated insulin secretion, and its altered palmitoylation contributes to β cell failure 2.