SCAMP3 (secretory carrier membrane protein 3) is a transmembrane recycling carrier that regulates post-Golgi trafficking and endosomal-lysosomal pathways 1. Mechanistically, SCAMP3 localizes to early endosomes and recycling endosomes, where it negatively regulates epidermal growth factor receptor (EGFR) degradation by interacting with ubiquitin ligases (Nedd4) and ESCRT machinery (Tsg101, Hrs) through its PY and PSAP motifs, thereby promoting receptor recycling to the cell surface 1. SCAMP3 also participates in pathogen-induced membrane trafficking, forming Salmonella-induced tubular networks during bacterial infection 2. SCAMP3 expression is regulated by a feed-forward loop involving miR-27a/b-3p and PPARG during adipogenesis, where SCAMP3 exhibits anti-adipogenic functions and correlates with insulin resistance 3. Disease relevance varies by context: in lung adenocarcinoma, SCAMP3 functions as a tumor suppressor by promoting EGFR degradation and attenuating MAP kinase signaling 4, while in breast cancer and prostate cancer, SCAMP3 promotes oncogenic progression through EGFR stabilization, ERK signaling, and stemness pathways 567. High SCAMP3 expression in breast cancer correlates with poor prognosis, chemoresistance, and reduced survival 5. These divergent roles suggest SCAMP3 context-dependently influences cancer progression and therapeutic resistance.