HomeAboutRankingsData Sources
© 2026 GeneE
🧬
GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
ⓘGeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
SLA
Src like adaptor
Chromosome 8 · 8q24.22
NCBI Gene: 6503Ensembl: ENSG00000155926.15HGNC: HGNC:10902UniProt: Q13239
45PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingepidermal growth factor receptor bindingsignal transductionregulation of MAPK cascadeovarian neoplasmcardiomyopathytesticular hydrocelesialolithiasis
✦AI Summary

The SLA (Src like adaptor) gene encodes an adapter protein that functions as a negative regulator of T-cell receptor (TCR) signaling pathways. The protein inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells and is involved in the negative regulation of positive selection and mitosis of T-cells 1. SLA may act by linking signaling proteins such as ZAP70 with CBL, leading to CBL-dependent degradation of signaling proteins. However, it is important to note that the provided abstracts primarily discuss different proteins or contexts also abbreviated as 'SLA' - including soluble liver antigen/liver pancreas (SLA/LP) in autoimmune hepatitis 21, swine leukocyte antigens in xenotransplantation 3, and stem-loop structures in dengue virus 4. The autoimmune hepatitis-related SLA/LP represents a distinct antigen that is actually the human SepSecS protein involved in selenocysteine formation 2. Due to the naming ambiguity across different biological contexts, the specific functional characterization of the Src like adaptor protein requires additional literature beyond what is provided in these abstracts.

Sources cited
1
Discusses SLA-specific CD4 T cells in autoimmune hepatitis context
PMID: 32649971
2
Identifies SLA/LP as human SepSecS protein involved in selenocysteine formation
PMID: 20623998
3
Describes SLA as swine leukocyte antigens in xenotransplantation
PMID: 32433239
4
References SLA as stem-loop structure in dengue virus replication
PMID: 37478848
⚠Limited data available — This gene has 4 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
ovarian neoplasmOpen Targets
0.41Moderate
cardiomyopathyOpen Targets
0.32Weak
testicular hydroceleOpen Targets
0.30Weak
sialolithiasisOpen Targets
0.30Weak
testicular diseaseOpen Targets
0.29Weak
exostosisOpen Targets
0.27Weak
Hashimoto's thyroiditisOpen Targets
0.26Weak
thyroid diseaseOpen Targets
0.25Weak
familial thyroid dyshormonogenesisOpen Targets
0.19Weak
genetic disorderOpen Targets
0.19Weak
Graves diseaseOpen Targets
0.15Weak
Back painOpen Targets
0.14Weak
brain aneurysmOpen Targets
0.12Weak
ovarian dysfunctionOpen Targets
0.08Suggestive
Okt4 epitope deficiencyOpen Targets
0.06Suggestive
Autoimmune HepatitisOpen Targets
0.06Suggestive
fungal lung infectious diseaseOpen Targets
0.04Suggestive
pneumoniaOpen Targets
0.04Suggestive
tooth diseaseOpen Targets
0.04Suggestive
neoplasmOpen Targets
0.03Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
STK40Shared pathway100%EGFRProtein interaction100%SLMAPProtein interaction90%NLRP2Protein interaction85%CBLProtein interaction85%FLT3Protein interaction80%
Tissue Expression6 tissues
Bone Marrow
100%
Lung
56%
Brain
12%
Liver
9%
Heart
4%
Ovary
4%
Gene Interaction Network
Click a node to explore
SLASTK40EGFRSLMAPNLRP2CBLFLT3
PROTEIN STRUCTURE
Preparing viewer…
PDB2CUD · NMR
View on RCSB ↗
Constraintⓘ
LOEUFⓘ
1.03LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF0.67 [0.45–1.03]
RankingsWhere SLA stands among ~20K protein-coding genes
  • #9,518of 20,598
    Most Researched45
  • #10,243of 17,882
    Most Constrained (LOEUF)1.03
Genes detectedSLA
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Structures of dengue virus RNA replicase complexes.
PMID: 37478848
Mol Cell · 2023
1.00
2
Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis.
PMID: 32649971
J Hepatol · 2020
0.90
3
Xenoantigens and xenoantibodies.
PMID: 9507728
Xenotransplantation · 1998
0.80
4
The Role of SLAs in Xenotransplantation.
PMID: 32433239
Transplantation · 2021
0.70
5
Human SepSecS or SLA/LP: selenocysteine formation and autoimmune hepatitis.
PMID: 20623998
Biol Chem · 2010
0.60