SLMAP (sarcolemma associated protein) functions as a scaffolding protein that associates with the STRIPAK (striatin-interacting phosphatase and kinase) complex, forming the extended (SIKE1:SLMAP)STRIPAK complex 1. This complex plays a crucial role in regulating the Hippo signaling pathway by dephosphorylating STK3, leading to Hippo pathway inhibition and control of cell growth 1. In cardiac function, SLMAP is essential for excitation-contraction coupling and cardiomyocyte contractility 23. All three SLMAP isoforms are expressed in cardiomyocytes and are significantly downregulated in human dilated cardiomyopathy 2. SLMAP-3 overexpression enhances cardiomyocyte response to adrenergic stimuli by increasing intracellular calcium transients and promoting positive chr3 effects 2. The protein interacts with striatin to regulate cardiac contraction, and loss of SLMAP function phenotypically mimics heart failure 2. SLMAP also contributes to DNA double-strand break repair through the Hippo-STRIPAK pathway, where STRIPAK-mediated MST1/2 inactivation increases DNA repair capacity in cancer cells 1. Genetic variants in SLMAP are associated with susceptibility to diabetic retinopathy and calcific aortic stenosis, highlighting its clinical relevance across multiple cardiovascular and metabolic conditions 45.