SNX18 is a PX-BAR domain sorting nexin protein that functions as a membrane-remodeling protein essential for multiple cellular processes. Primarily, SNX18 regulates endocytosis and intracellular vesicle trafficking through its capacity to tubulate phosphatidylinositol 4,5-bisphosphate-enriched membranes and promote dynamin-2 GTPase activity 12. SNX18 participates in clathrin-dependent and clathrin-independent endocytosis at the plasma membrane with functional redundancy alongside SNX9 2, and mediates β-arrestin-independent GPCR endocytosis of receptors such as CXCR4 3. SNX18 is also critical for cytokinesis completion and mitotic progression, functioning in both endocytosis-dependent and -independent mechanisms by regulating myosin regulatory light chain localization and Rab11-positive recycling endosome recruitment to the intracellular bridge 4. Mechanistically, SNX18 regulates autophagosome biogenesis by recruiting dynamin-2 to recycling endosomes to facilitate ATG9A and ATG16L1-containing membrane trafficking and LC3 lipidation 56. Additionally, SNX18 cooperates with FIP5 in polarized protein transport during epithelial lumen formation 7. Disease relevance remains understudied, though SNX18 dysfunction could impact autophagy-related conditions and cellular trafficking defects.