SNX33 is a sorting nexin family protein that plays critical roles in cellular membrane trafficking, cytoskeletal organization, and cell division. The protein is essential for proper mitotic progression and cytokinesis completion, with depletion causing multinucleation and cytokinesis failure 1. SNX33 functions through both endocytosis-dependent and -independent mechanisms during cell division, affecting chromosome 15 and MRLC localization during ingression 1. The protein modulates endocytosis of cell-surface proteins including amyloid precursor protein (APP) and prion protein (PrP), thereby influencing their proteolytic processing 2 3. SNX33 reduces APP endocytosis by interacting with dynamin, leading to increased APP at the plasma membrane where α-secretase cleavage occurs, promoting the non-amyloidogenic pathway and reducing amyloid-β generation 2 4. Similarly, SNX33 overexpression increases PrP shedding from the plasma membrane and reduces pathogenic PrP conversion 3. The protein mediates cytoskeletal reorganization through interaction with Wiskott-Aldrich syndrome protein (WASP), affecting actin polymerization and cell cycle progression 5. SNX33 also interacts with ADAM15 through SH3 domain binding, demonstrating its role in coordinating membrane protein trafficking and signaling 6.