SNX6 (sorting nexin 6) is a PX and BAR domain-containing protein that functions as a transient component of the retromer complex, mediating retrograde endosome-to-trans-Golgi network (TGN) transport 1. SNX6 forms heterodimeric complexes with SNX1 and participates in cargo selection and membrane remodeling to generate endosome-to-TGN transport carriers 2. The protein binds phosphoinositide-enriched endosomal membranes and coordinates with the retromer cargo-recognition trimer (Vps26/Vps29/Vps35) to retrieve cargoes including the cation-independent mannose-6-phosphate receptor 3. SNX6 negatively regulates BACE1 retrograde transport, thereby suppressing amyloid-beta production relevant to Alzheimer's disease pathogenesis 4. Additionally, SNX6 modulates E-cadherin sorting and interacts with GIT1 to promote EGFR lysosomal degradation 5. Beyond trafficking functions, SNX6 regulates PD-L1 expression by modulating Cullin3-mediated ubiquitination, influencing cancer immune evasion 6. SNX6 expression correlates with poor prognosis in pancreatic cancer and promotes epithelial-mesenchymal transition 7. SNX6 also interacts with Rab32 to affect retromer-dependent Golgi trafficking, potentially linking this protein to Parkinson's disease-associated pathways 8.