SNX32 is a sorting nexin protein with BAR and PX domains that mediates endosomal trafficking of multiple cargo proteins. It functions primarily in sorting and trafficking of activated EGFR to multivesicular bodies for lysosomal degradation, working in parallel with SNX1 and coordinately with SNX5 1. SNX32 directly interacts with EGFR and recruits SNX5 to promote EGF-stimulated postendocytic trafficking 1. It also functions redundantly with other BAR domain-containing sorting nexins in endosome-to-trans-Golgi network transport of the cation-independent mannose-6-phosphate receptor (CI-MPR) 1. Beyond receptor trafficking, SNX32 plays essential roles in neurite outgrowth by controlling basigin (BSG) cell surface trafficking. Clinically, SNX32 has emerged as a significant Alzheimer's disease (AD) risk gene. Integrative proteomic and genetic analyses identified SNX32 brain protein abundance as causally associated with AD (P<0.05) 2, with SNX32 also showing association at the blood transcriptomic level 2. Functional studies in Drosophila demonstrate that loss of SNX32 orthologs (Snx6) causes neurodegeneration 3, 4. Additionally, SNX32 was identified as part of a 6-gene prognostic signature for lung squamous cell carcinoma associated with COPD 5, and has been investigated as a potential breast cancer susceptibility locus 6.