SRCAP (Snf2-related CREBBP activator protein) is an ATP-dependent chr16 remodeler that functions as the catalytic component of the SRCAP complex, mediating histone variant exchange and transcriptional regulation 12. The protein catalyzes ATP-dependent exchange of histone H2A.Z/H2B dimers for nucleosomal H2A/H2B, thereby modulating chr16 accessibility and gene expression 34. SRCAP acts as a coactivator for CREB-, steroid receptor-, and Notch-mediated transcription 567, and coordinates H2A.Z deposition at target gene promoters to regulate oncogenic transcription programs 4. Clinically, SRCAP mutations cause distinct neurodevelopmental phenotypes. Truncating variants in exons 33-34 cause Floating-Harbor syndrome, characterized by growth deficiency and skeletal abnormalities 8. Conversely, truncating variants proximal or distal to the FLHS locus cause non-FLHS SRCAP-related neurodevelopmental disorder with developmental delay, intellectual disability, behavioral problems, hypotonia, and musculoskeletal issues, exhibiting a distinct DNA methylation signature 9. Additionally, SRCAP mutations promote clonal hematopoiesis through dysregulated DNA repair and H2A.Z deposition, conferring selective advantage in hematopoietic stem cells 10. SRCAP alterations also occur in colorectal cancer and uterine leiomyomas, suggesting broader roles in tumorigenesis 113.