SV2C (synaptic vesicle glycoprotein 2C) is a member of the SV2 protein family that plays a critical role in synaptic vesicle function and dopamine neurotransmission 1. The protein is primarily expressed in phylogenetically old brain regions, particularly the basal ganglia including substantia nigra, ventral tegmental area, dorsal striatum, and nucleus accumbens, where it localizes to dopaminergic, GABAergic, and cholinergic neurons 2. SV2C functions as a mediator of dopamine homeostasis by regulating synaptic vesicle exocytosis and dopamine release in the dorsal striatum 1. Genetic deletion of SV2C leads to reduced dopamine release, decreased striatal dopamine content, disrupted α-synuclein expression, and motor function deficits 1. The protein serves as a receptor for botulinum neurotoxin type A and D 34. SV2C has significant clinical relevance in Parkinson's disease (PD), where its expression is dramatically altered in postmortem brain tissue from PD cases 1. A common missense variant (p.Asp543Asn) has been identified as a PD risk factor through genome-wide association studies 5, and SV2C serves as a potential diagnostic biomarker with decreased expression in PD patients' serum 6. The protein represents a promising therapeutic target for neurological disorders involving dopaminergic dysfunction.