TCEANC (transcription elongation factor A N-terminal and central domain containing) is an X-linked gene with established roles in transcriptional regulation and disease susceptibility. Functionally, TCEANC encodes a protein containing N-terminal and central domains characteristic of transcription elongation factors and exhibits protein binding activity within the nucleus 1. The gene participates in transcription elongation by RNA polymerase II, with evidence suggesting it functions as a transcription elongation factor 1. Mechanistically, TCEANC interacts with BRCA1, a breast and ovarian tumor suppressor, and participates in the response to transcription-associated DNA damage, including transcription restart after UV damage and prevention of R-loop-mediated damage 1. As an X-linked gene, TCEANC is subject to X chromosome X regulation, though it demonstrates variable inactivation status across tissues and disease states 23. Disease relevance is substantial: TCEANC variants associate with late-life memory decline in females, with an X-chromosome X (rs5935633) linked to memory performance differences between sexes 4. Additionally, TCEANC shows dysregulated X inactivation patterns in ovarian cancer, correlating with worse clinical outcomes including shorter recurrence and overall survival times 2. TCEANC has also been identified in genome-wide association studies of hypertension susceptibility 5, suggesting broader cardiovascular relevance.