TEX264 is a major endoplasmic reticulum (ER)-resident reticulophagy receptor that mediates selective autophagic degradation of ER subdomains 1. As an ER protein with a single transmembrane domain and an LC3-interacting region (LIR) motif, TEX264 interacts with LC3 and GABARAP family proteins to bridge ER and autophagosomal membranes 2. During nutrient stress, TEX264 recognizes tubular ER segments near three-way junctions and recruits them into ATG8-containing isolation membranes through trans interactions, facilitating autophagosomal enclosure and lysosomal fusion for ER turnover 1. An intrinsically disordered region enables its ER-phagy function independent of amino acid sequence 2. Beyond ER homeostasis, TEX264 functions in DNA repair by sensing topoisomerase 1 cleavage complexes (TOP1cc) at replication forks and coordinating their resolution with the p97 ATPase and SPRTN metalloprotease 3. This dual role promotes lysosomal processing of TOP1cc lesions and facilitates cell survival after topoisomerase inhibition 4. TEX264-mediated reticulophagy also contributes to autophagic cell death responses under ER stress conditions 5, with potential implications for viral defense mechanisms 6. These multifaceted functions establish TEX264 as a critical regulator of ER quality control and genome stability.