TFPT (TCF3 fusion partner) is a putative regulatory component of the INO80 chr19 remodeling complex involved in transcriptional regulation, DNA replication, and DNA repair 1. The gene encodes a highly conserved protein across mammalian species 2 and is regulated by hematopoietic transcription factors including PU.1 and Ikaros 2, suggesting a role in hematopoiesis 2. TFPT promotes caspase 9-dependent apoptosis in a p53-independent manner, though this apoptotic response is cell-type restricted and influenced by cell density and proliferation conditions 3. SUMOylation of TFPT is critical for its interaction with INO80E within the INO80 complex 1. Clinically, TFPT gained prominence through its identification as a fusion partner of TCF3 in childhood pre-B acute lymphoblastic leukemia 2, implicating it in leukemogenesis. Additionally, TFPT shares regulatory elements with PRPF31 in a head-to-head chr19 arrangement at 19q13.4; differential TFPT expression may influence PRPF31-associated retinitis pigmentosa penetrance 45. Despite these functional associations, TFPT's specific molecular role remains incompletely characterized.