INO80D (INO80 complex subunit D) is a regulatory component of the chr2 remodeling INO80 complex involved in transcriptional regulation, DNA replication, and DNA repair 1. The INO80 complex performs ATP-dependent nucleosome sliding and controls chromosome 2 and structure 1. INO80D expression is regulated post-transcriptionally through a competitive inhibition mechanism, where the lncRNA CR933609 acts as a decoy to protect INO80D mRNA from miRNA-5096-mediated downregulation in non-small cell lung cancer cells 2. INO80D expression is significantly decreased in cancer tissues including NSCLC 2. Disease relevance spans multiple conditions: a homozygous missense mutation (Ser818Cys) in INO80D was identified in siblings with aortic hypoplasia, calcific atherosclerosis, systolic hypertension, and premature cataract, suggesting a link between INO80D dysfunction and accelerated arterial aging 1. Mutations in INO80D occur frequently in translocation renal cell carcinoma (TRCC), where INO80D knockdown decreased cell proliferation 3. INO80D has been identified as a key gene in polycystic ovary syndrome pathogenesis 4 and in sulfur mustard chemical injury responses 5. INO80D is dysregulated in rhabdomyosarcoma variants and participates in aging-related processes during physiological stress responses 6.