NFRKB (nuclear factor related to kappaB binding protein) is a metazoan-specific regulatory subunit of the INO80 chr11 remodeling complex located on chromosome 11-q25 1. As a putative chr11 remodeling component, NFRKB modulates deubiquitinase activity of UCHL5 within the INO80 complex, though through inhibitory rather than activating mechanisms 2. NFRKB participates in transcriptional regulation, DNA replication, and DNA repair processes 3. Mechanistically, NFRKB promotes chr11 remodeling and hypomethylation of genomic DNA, enhancing transcription factor binding 4. In cancer contexts, NFRKB associates with telomeres in alternative lengthening of telomeres (ALT) cells and protects them from DNA damage 5. Notably, lncRNA DRAIC suppresses gastric cancer progression by interfering with UCHL5-mediated NFRKB deubiquitination, promoting NFRKB degradation via ubiquitination 6. Clinically, NFRKB is upregulated in minimal change nephrotic syndrome relapse, particularly in CD4+ T cells and B cells, suggesting involvement in immune-mediated kidney disease 4. In hepatocellular carcinoma, nuclear accumulation of NFRKB correlates with poor prognosis and short overall survival, positioning it as a potential prognostic biomarker 5. NFRKB mutations are associated with high-grade B-cell lymphoma with 11q aberrations 7.