THRSP (thyroid hormone responsive protein) is a lipogenic nuclear protein that plays crucial roles in fatty acid synthesis and metabolic regulation. The protein maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes, with its expression being insulin-inducible in a PI3K-dependent manner 1. THRSP promotes hepatic palmitic acid synthesis by enhancing de novo lipogenesis and inhibiting FASN ubiquitination through disrupting FASN-TRIM21 binding 2. In cancer contexts, THRSP expression is suppressed and associated with better prognosis in hepatocellular carcinoma, where decreased expression promotes tumor progression through NF-κB, ERK1/2, and p38 MAPK signaling pathways 3. The protein also regulates fatty acid synthase gene expression, as demonstrated by conjugated linoleic acid's ability to inhibit both THRSP and fatty acid synthase genes, leading to growth inhibition in breast cancer and liposarcoma cells 4. Additionally, THRSP appears to have neurological significance, with overexpression linked to ADHD predominantly inattentive presentation through altered Wnt signaling in hippocampal dentate gyrus, affecting neural stem cell activity and behavioral outcomes 5. These findings establish THRSP as a multifunctional regulator of lipid metabolism with implications for metabolic diseases, cancer, and neurological disorders.