TOMM70 is a 70 kDa adaptor protein that functions as a receptor component of the translocase complex of the outer mitochondrial membrane (TOM complex), facilitating the import of mitochondrial preproteins from the cytosol 1. The protein recognizes cytosolic chaperones through its tetratricopeptide repeat (TPR) domain and mediates translocation of preproteins lacking positively charged mitochondrial targeting sequences 2. Mechanistically, TOMM70 maintains mitochondrial function by enabling protein import and supporting mitochondrial bioenergetics, particularly during cellular stress conditions 2. Beyond its canonical import function, TOMM70 plays crucial roles in antiviral immunity by interacting with viral proteins such as SARS-CoV-2 ORF9b, which hijacks this interaction to suppress innate immune responses 34. The protein also facilitates PINK1 stabilization at the outer mitochondrial membrane, promoting mitophagy through disruption of normal PINK1 import and preventing its cleavage 5. Clinically, TOMM70 deficiency has been observed in diabetic foot ulcers, where macrophage-derived exosomal TOMM70 compensates for hypoxia-induced depletion in keratinocytes 2. Additionally, TOMM70 upregulation has been implicated in osteoarthritis therapy through restoration of ER-mitochondria-calcium homeostasis 6, highlighting its therapeutic potential in metabolic and inflammatory diseases.