TOMM7 encodes a component of the translocase of the outer mitochondrial membrane (TOM) complex that is essential for mitochondrial protein import and mitophagy regulation 1. The protein facilitates recognition and translocation of cytosolically synthesized mitochondrial preproteins into mitochondria 1. TOMM7 plays a crucial role in PINK1/Parkin-mediated mitophagy by regulating intracellular redistribution of phospholipase PLA2G6 between the nucleus and mitochondria 2. Loss-of-function variants in TOMM7 cause severe metabolic reprogramming, shifting cellular energy production from oxidative phosphorylation to glycolysis 3. Disease-causing mutations lead to autosomal recessive progeroid syndrome characterized by severe dwarfism, mandibular hypoplasia, and partial lipodystrophy 1, as well as microcephalic osteodysplastic dwarfism with moyamoya disease 3. TOMM7 dysfunction results in enlarged mitochondria, increased cellular senescence, and defective angiogenesis 3. The gene also shows prognostic significance in multiple myeloma and clear cell renal cell carcinoma, where altered expression correlates with patient outcomes 45.