TRIM43 is an E3 ubiquitin ligase that functions as a herpesvirus-specific antiviral factor by regulating nuclear lamina integrity 1. The protein ubiquitinates the centrosomal protein pericentrin (PCNT), targeting it for proteasomal degradation, which alters nuclear lamina structure and represses active viral chr2 states 1. This mechanism restricts replication of a broad range of herpesviruses, including Kaposi's sarcoma-associated herpesvirus 1. TRIM43 expression is profoundly upregulated during herpesvirus infection as part of a germline-specific transcriptional program mediated by the transcription factor DUX4, highlighting its role in intrinsic antiviral immunity 1. Beyond viral defense, TRIM43 is significantly overexpressed in facioscapulohumeral muscular dystrophy (FSHD) tissues during both fetal and adult stages, suggesting a role in muscle pathology 2. The TRIM43-pericentrin-lamin axis represents a potential therapeutic target for herpesviral infections 1. TRIM43 is also expressed during early embryo development, showing paternal genome contribution to zygote genome activation 3.