TUBE1 (tubulin epsilon 1) is a centrosomal protein essential for centriole structure and function. It localizes to centrioles where it binds to A-microtubules and maintains microtubule integrity as part of the centriole biogenesis pathway 1. TUBE1 is required for centriole-to-centrosome conversion, a critical maturation step in centrosome duplication during the mitotic cell cycle 1. Loss-of-function variants in TUBE1 disrupt centriole microtubule integrity and impair this conversion process 1. Functionally, TUBE1 contributes to cytoskeleton organization and cell migration 2. Clinically, rare loss-of-function variants in TUBE1 have been identified in children with bladder exstrophy, a rare congenital urogenital defect, suggesting a role in developmental cell migration processes 2. Additionally, TUBE1 has been identified as a differentially expressed gene in several cancer contexts. It was included in ferroptosis-related gene signatures predictive of overall survival in rectal cancer 3 and skin cutaneous melanoma 4, and in mitotic cell cycle gene signatures for hepatocellular carcinoma diagnosis 5. However, TUBE1 showed no significant expression difference in rectal cancer tissue 3. TUBE1 has also been evaluated as a candidate gene in inherited occipital polymicrogyria 6, though mutations were not reported.