TEDC2 (tubulin epsilon and delta complex 2) is a centriolar protein essential for centriole architecture and ciliary signaling. Primary function: TEDC2 acts as a positive regulator of ciliary hedgehog signaling 1 and is required for centriole stability 2. Mechanism: TEDC2 physically interacts with delta-tubulin, epsilon-tubulin, and TEDC1 to form a tetramer complex that promotes robust centriole architecture, particularly triplet microtubule formation and central core scaffold protein recruitment 2. Loss of TEDC2 results in abnormal centrioles with expanded proximal regions, absent triplet microtubules, and mitotic fragmentation 2. Disease relevance: Biallelic TEDC1 variants (which require TEDC2 binding) cause severe growth impairment, microcephaly, developmental delay, and endocrine complications, with evidence of cell cycle abnormalities and cilia defects 3. Clinical significance: TEDC2 is aberrantly overexpressed in multiple solid tumors and correlates with poor prognosis in lung adenocarcinoma, kidney renal clear cell carcinoma, and hepatocellular carcinoma 456. TEDC2 promotes non-small cell lung cancer progression through hedgehog pathway activation and cancer stem cell maintenance; TEDC2 knockdown enhances chemotherapy sensitivity 1. High TEDC2 expression associates with reduced immune infiltration and increased immune checkpoint expression, suggesting dual roles in centriolar function and tumor progression 56.