TEDC1 (tubulin epsilon and delta complex 1) functions as a critical component of the centriole assembly complex, working together with delta-tubulin, epsilon-tubulin, and TEDC2 to establish proper centriole architecture 1. The protein localizes to centrosomes and is mutually dependent on delta-tubulin and epsilon-tubulin for proper localization, forming a physical subcomplex essential for triplet microtubule formation and central core scaffold protein recruitment 1. TEDC1 also positively regulates ciliary hedgehog signaling through mechanisms involving cilia stability and acetylated tubulin homeostasis 2. Clinically, biallelic TEDC1 mutations cause primary autosomal recessive microcephaly (MCPH), a neurodevelopmental disorder characterized by cognitive impairment, reduced brain size, and delayed neurodevelopment 3. More broadly, TEDC1 deficiency manifests as a severe multisystem syndrome including prenatal growth impairment, microcephaly, developmental delay, adrenal insufficiency, congenital glaucoma, craniosynostosis, and gonadal dysgenesis 2. Loss-of-function TEDC1 variants impair cell cycle progression and cilia formation through defective tubulin acetylation 2. TEDC1 represents an important centrosome-related pathway gene in primary microcephaly pathogenesis 4.