UBXN2A (UBX domain protein 2A) is a ubiquitin-like protein that functions as a multifaceted regulator of protein stability and cellular signaling. As a p97 adaptor protein, UBXN2A represses CHIP-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of the nicotinic acetylcholine receptor subunit CHR2 in cortical neurons, thereby promoting its trafficking to the plasma membrane 1. Conversely, UBXN2A positively mediates proteasomal degradation of RICTOR, a core component of the mTORC2 complex, thereby suppressing this oncogenic signaling pathway 23. UBXN2A also inhibits STUB1-mediated TP53 degradation through interaction with HSPA9, stabilizing the p53 tumor suppressor 4. In cancer biology, UBXN2A functions as a tumor suppressor: it enhances CHIP-dependent degradation of the oncoprotein mortalin-2, suppressing epithelial-mesenchymal transition and chemotherapy resistance 54. UBXN2A expression is often reduced in colorectal cancer tissues, and its pharmacological upregulation via veratridine sensitizes cancer cells to chemotherapy 67. Recent genome-wide association studies identify UBXN2A as a causal gene associated with lung function traits (FEV1 and FVC), suggesting broader physiological relevance beyond cancer 8.