WWC1 (WW and C2 domain containing 1) is a critical regulator of the Hippo signaling pathway that functions as a tumor suppressor and synaptic plasticity modulator. WWC1 acts as an organizer protein that directly interacts with LATS1/2 kinases and SAV1, facilitating MST1/2-mediated phosphorylation and activation of LATS1/2 1. This leads to phosphorylation of YAP/TAZ transcription factors, ultimately suppressing their oncogenic activity and inhibiting cell proliferation and organ growth 1. In cancer contexts, WWC1 functions as a tumor suppressor, with low expression associated with aggressive breast cancer, poor survival outcomes, and advanced-stage disease 2. WWC1 protein stability is regulated through ubiquitination and proteasomal degradation, with NF2 promoting its degradation via β-TrCP1/2 E3 ligases, and palmitoylation by ZDHHC15 also leading to its degradation 34. Beyond cancer, WWC1 plays important roles in synaptic function and memory, regulating AMPAR trafficking and synaptic plasticity 5. Loss-of-function mutations like W88C are associated with neurodevelopmental disorders including Tourette's syndrome, causing synaptic dysfunction and behavioral deficits 6. These findings establish WWC1 as a multifunctional protein with therapeutic potential in both cancer and neurological disorders.