WWC3 is an X-linked scaffolding protein that functions as a negative regulator of cell proliferation and organ growth by activating the Hippo signaling pathway 1. WWC3 enhances phosphorylation of LATS1/2 kinases, leading to phosphorylation and cytoplasmic retention of YAP1, thereby suppressing its transcriptional activity and reducing expression of pro-proliferative genes 2. Additionally, WWC3 interacts with Dishevelled proteins to inhibit Wnt/β-catenin signaling, providing a molecular link between the Hippo and Wnt pathways 34. Clinically, WWC3 acts as a tumor suppressor across multiple cancer types. WWC3 downregulation is associated with poor prognosis in gastric cancer, correlating with advanced stage, nodal metastasis, and decreased survival 5. Similarly, reduced WWC3 expression in lung cancer correlates with low differentiation, advanced stage, and poor outcomes; WWC3 overexpression inhibits lung cancer invasion and metastasis 3. In glioma, WWC3 suppresses cell proliferation and invasion through Wnt pathway inhibition 4. Beyond cancer, WWC3 expression correlates with tumor volume response to somatostatin analog treatment in growth hormone-producing pituitary adenomas, suggesting roles in endocrine tumor biology 6.