YIPF2 (Yip1 domain family member 2) is a trans-Golgi-localized transmembrane protein that functions as a Rab-GDF (GDI-displacement factor) regulating vesicular trafficking and protein recycling 1. The protein contains a cytosolic N-terminal domain and five transmembrane domains with a luminal C-terminus 2, and localizes to medial-/trans-Golgi and trans-Golgi network compartments 3. Mechanistically, YIPF2 regulates endocytic recycling by recruiting and activating Rab5 and Rab22a GTPases, modulating cargo protein glycosylation and trafficking through the ER-Golgi pathway 1. It also mediates surface recycling of TNFRSF10B through RAB8 inhibition 4 and controls CD147-MCT1 complex assembly critical for monocarboxylate transport 5. Dysregulation of YIPF2 associates with multiple diseases. In hepatocellular carcinoma, YIPF2 overexpression promotes CD147-dependent malignant phenotypes including enhanced migration and invasion 1. In non-small cell lung cancer, YIPF2 upregulation enhances chemotherapy-induced apoptosis via TNFRSF10B recycling 4. YIPF2 also contributes to osteoarthritis-related synovitis pathogenesis 6 and diabetic encephalopathy through CD147 trafficking modulation 5. YIPF2 knockdown delays Golgi reassembly and reduces glycosylation capacity 3, indicating essential roles in secretory pathway homeostasis.