ZBTB17 is a zinc finger transcription factor functioning as both activator and repressor depending on binding partners, with critical roles across multiple biological systems. In early development, ZBTB17 is essential for peri-implantation embryogenesis, collaborating with KDM6A/B to resolve bivalent chr1 and prime pluripotency gene activation 1. It regulates lymphocyte development by preventing apoptosis in lymphoid precursors and promoting lineage commitment 2. In cardiac physiology, ZBTB17 protects cardiomyocytes from apoptosis and regulates hypertrophy; loss-of-function mutations cause dilated cardiomyopathy with autosomal dominant inheritance 34. Beyond development, ZBTB17 promotes peroxisome biogenesis by transcriptionally regulating PEX13, affecting peroxisomal protein import and nucleotide metabolism 5. Mechanistically, ZBTB17 modulates the NF-κB signaling pathway, with dysregulation implicated in Alzheimer's disease and atherosclerosis pathogenesis 6. The protein's multifaceted regulatory roles position it as a disease candidate gene with therapeutic potential in cardiovascular and neurodegenerative conditions.