ZC3H10 is a CCCH-type zinc finger protein with dual functions in gene regulation and cellular metabolism. As a post-transcriptional regulator, ZC3H10 binds to specific RNA sequences (5'-GCAGCGC-3') on pri-miR143 through its zinc finger domains to negatively regulate miRNA processing 1. Beyond miRNA regulation, ZC3H10 functions as a transcription factor activating the UCP1 promoter in brown adipose tissue thermogenesis. Upon sympathetic stimulation, p38 MAPK phosphorylates ZC3H10 at S126, enhancing its binding to the distal UCP1 promoter region and promoting thermogenic gene expression 2. ZC3H10 also acts as a mitochondrial regulator; its upregulation during myoblast differentiation enhances mitochondrial function and electron transport chain expression, while depletion impairs mitochondrial physiology and myoblast differentiation 3. A human loss-of-function mutation (Tyr105Cys) associates with metabolic dysfunction including increased body mass index and reduced oxygen consumption 3. Clinically, ZC3H10 appears tumor-suppressive, inhibiting anchorage-independent growth in breast cancer cells 4, and influences glioma chemotherapy sensitivity to temozolomide 5. These findings suggest ZC3H10 as a therapeutic target for obesity and cancer management.