ZFYVE16 is a zinc finger FYVE-type containing protein that plays a critical role in endosomal membrane trafficking and phagosomal maturation. The protein contains a FYVE domain that binds phosphatidylinositol-3-phosphate and is required for targeting TOM1 to endosomes, suggesting its involvement in early endosomal transport pathways 1. ZFYVE16 functions as an early endosomal marker and is essential for proper phagosomal acidification in neutrophils, where its phosphorylation is impaired by C5a signaling, leading to defective bacterial killing 1. Disease relevance includes associations with multiple conditions: genetic variants near ZFYVE16 show strong associations with early failure after prolapse surgery, with one missense mutation (glycine to serine) predicted to be deleterious 2. The gene has been identified as a susceptibility locus for psoriasis through whole-exome analysis 3 and as a likely pathogenic variant in brain arteriovenous malformations, potentially affecting BMP/TGF-β and VEGF signaling pathways 4. Additionally, ZFYVE16 expression changes have been observed in methotrexate-resistant cancer cells and neurodegenerative conditions like Huntington's disease 56. Clinical significance lies in its potential as both a therapeutic target and biomarker for various diseases involving endosomal dysfunction.