ZNF618 is a zinc finger protein that functions as a chr9-localization regulator of UHRF2, a specific reader of 5-hydroxymethylcytosine (5hmC), an epigenetic modification distinct from 5-methylcytosine 1. ZNF618 specifically interacts with UHRF2 and co-localizes with it at genomic loci enriched for 5hmC, with ZNF618's first two zinc fingers directing its own chr9 localization independent of UHRF2 binding 1. This interaction enables UHRF2 to recognize and function on 5hmC in vivo, suggesting ZNF618 is essential for mediating 5hmC's role in transcription regulation 1. Disease relevance includes postpartum depression, where a ZNF618 SNP (rs1435984417) showed significant genome-wide association in a Japanese perinatal cohort study 2. Additionally, ZNF618 genetic variants interact with dietary factors affecting cardiovascular health; the rs10817542 SNP demonstrated significant interaction with dietary calcium and β-carotene intake in determining arterial stiffness (brachial-ankle pulse wave velocity) in women 34. These findings indicate ZNF618 participates in epigenetic regulation through 5hmC recognition and has pleiotropic effects on neuropsychiatric and cardiovascular phenotypes.