ZNF622 is a zinc finger protein with dual roles in ribosomal biogenesis and antiviral immunity. As a pre-60S-associated cytoplasmic factor, ZNF622 participates in late-stage maturation of the 60S ribosomal subunit, interacting with cofactors PA2G4 and nucleophosmin 1 (NPM1) 1. ZNF622 functions as a novel cellular antiviral protein, limiting human adenovirus replication by restricting pVII protein binding to viral DNA and forming a trimeric complex with pVII and NPM1 2. It also exhibits antiviral activity against coronaviruses, identified as a novel ER quality control factor in coronavirus-infected cells 3. ZNF622 regulates apoptosis through phosphorylation-dependent mechanisms. Phosphorylation at Ser143 suppresses ZNF622-mediated stress-induced apoptosis, with DUSP12 protecting cells by dephosphorylating ZNF622 at this site 4. Beyond defense functions, ZNF622 shows disease relevance in cancer, with DNA methylation of ZNF622 differentially associated with nonalcoholic fatty liver disease progression 5, and ZNF622 overexpression occurring in peritoneal carcinomatoses from colorectal cancer 6. ZNF622 additionally participates in excised intron RNA (FLEXI) regulation as an RNA-binding protein with cytoplasmic functions 7.