ANAPC2 is a core catalytic subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and G1 phase 1. The protein contains a zinc-binding module that confers structural stability to the APC/C complex 1. ANAPC2 mediates ubiquitination through formation of Lys-11-linked polyubiquitin chains and functions in the ubiquitin-proteasome degradation pathway 23. Beyond cell cycle regulation, ANAPC2 plays roles in immune modulation and cancer biology. Mycobacterium tuberculosis exploits ANAPC2 to suppress host immunity by facilitating Lys-11-linked ubiquitination of the mycobacterial protein Rv0222, which prevents TRAF6 activation and proinflammatory cytokine expression 2. In colorectal cancer, ANAPC2 upregulation promotes KRAS protein degradation through the ubiquitin-proteasome pathway, suggesting therapeutic potential 3. ANAPC2 also affects adipocyte function, with overexpression inhibiting adipogenesis, potentially influencing body fat distribution 4. Additionally, ANAPC2 contributes to tissue integrity during collective cell migration, as its loss causes detachment phenotypes in developmental contexts 5. The protein's methylation status correlates with drug sensitivity in cancer cells 6.